Endocrine Abstracts

Adrenocortical carcinoma (ACC) is a rare endocrine cancer with a poor prognosis. Roughly 10–15% of all ACCs arise in patients with a predisposition to cancer development due to a germline mutation. Pediatric ACC is a well-described core malignancy of the Li Fraumeni syndrome tumour spectrum. More recently TP53 mutations have also been found in adult ACC patients. In addition recent advances in clinical and molecular genetics have identified additional familial ca...